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Subsystem: Alkane biosynthesis in bacteria

This subsystem's description is:

A novel alkane biosynthesis pathway from cyanobacteria that consists of an acyl-acyl carrier protein reductase and an aldehyde decarbonylase, which together convert intermediates of fatty acid metabolism to alkanes and alkenes. The heterologous expression of the alkane operon in Escherichia coli leads to the production and secretion of C13 to C17 mixtures of alkanes and alkenes.
As suggested by Schirmer and Co. "These genes and enzymes can now be leveraged for the simple and direct conversion of renewable raw materials to fungible hydrocarbon fuels."
The operon is actually larger and includes adjacent genes coding for Sepiapterin reductase (EC 1.1.1.153) and GTP cyclohydrolase I (EC 3.5.4.16) type 1 (see subsystem "Pterin synthesis related cluster") and connect this alkane biosynthesis pathway to Pterin and Folate biosynthesis.

For more information, please check out the description and the additional notes tabs, below

Diagram	Functional Roles	Subsystem Spreadsheet	Description	Additional Notes
Oops! We thought there was a diagram here, but we can't find it. Sorry Group Alias Abbrev. Functional Role Reactions Scenario Reactions GO Literature Subsets Coloring collapsed expanded do not color by cluster by attribute: BS_essential_Kobayashi EC_contribute_to_fitness EC_essential_Blattner EC_essential_Keio EC_essential_Shigen Essential_Gene_Sets_Bacterial HP_candidate_essential_Salama MG_essential_Hutchison_2006 MT_contribute_to_fitness_Rubin PA_candidate_essential_Jacobs PA_essential_PA14_PAO1_Liberati SA_essential_Forsyth SA_essential_Ji SA_essential_merged_Forsyth_and_Ji SP_essential_merged SP_essential_Song SP_essential_Thanassi ST_essential_Knuth CELLO cell_surface established_antibiotic_inhibitor established_antibiotic_target GENE3D iedb_epitopelinearsequence iedb_epitopename in_phage isoelectric_point microarray_sigmaB_regulon molecular_weight mouse_passage_in_THY_18_hours_change PANTHER PDB Phobius PRINTS PROFILE PSORT PSORT_score secreted_protein_signal SignalP similar_to_human SMART SSF structure TIGRFAMs toxin Vibrio_Fe-regulated_Mey2005 Vibrio_Fur-regulated_Mey2005 virulence_associated virulence_associated_by_adhesion_properties_of_mutants virulence_associated_by_evolution_of_epidemic_microarray virulence_associated_by_mutagenesis_and_nematode_killing virulence_associated_by_Rot_expression_analysis virulence_associated_by_screening_mutants_in_murine_model virulence_associated_by_site_specific_mutation virulence_associated_by_vaccination    Taxonomy  Pattern  Organism  Domain Variant Variant Codes -1 Subsystem is not present 0 presence unknown * computer assessed variant (not confirmed by annotator) others functional variant [?]  =!= active AldDec AAR ACoATra Aldehyde decarbonylase Acyl-ACP reductase Acetyl-coenzyme A carboxyl transferase alpha chain (EC 6.4.1.2) A novel alkane biosynthesis pathway from cyanobacteria that consists of an acyl-acyl carrier protein reductase and an aldehyde decarbonylase, which together convert intermediates of fatty acid metabolism to alkanes and alkenes. The heterologous expression of the alkane operon in Escherichia coli leads to the production and secretion of C13 to C17 mixtures of alkanes and alkenes. As suggested by Schirmer and Co. "These genes and enzymes can now be leveraged for the simple and direct conversion of renewable raw materials to fungible hydrocarbon fuels." The operon is actually larger and includes adjacent genes coding for Sepiapterin reductase (EC 1.1.1.153) and GTP cyclohydrolase I (EC 3.5.4.16) type 1 (see subsystem "Pterin synthesis related cluster") and connect this alkane biosynthesis pathway to Pterin and Folate biosynthesis. SS started by RamyA and extended by VeronikaV This subsystem is based on a paper by Schirmer and coworkers published in Science in July 2010 [Science. 2010 Jul 30;329(5991):559-62. PMID: 20671186]