Subsystem: Copper Transport System
This subsystem's description is:
The copper ion is important for biological processes because it acts as a cofactor in many enzymes. The ycn operon encodes proteins that are utilized in copper uptake in copper-limiting conditions. The ycnK,copC, copD, and ycnI genes are polycistronic while the ycnL gene is monocistronic and read in the opposite direction. Copper efflux is encoded in the copZA operon with the csoR gene acting as the transcriptional repressor of the operon.
For more information, please check out the description and the additional notes tabs, below
| Literature References | Copper acquisition is mediated by YcnJ and regulated by YcnK and CsoR in Bacillus subtilis. Chillappagari S Journal of bacteriology 2009 Apr | 19168619 | Direct and indirect regulation of the ycnKJI operon involved in copper uptake through two transcriptional repressors, YcnK and CsoR, in Bacillus subtilis. Hirooka K Journal of bacteriology 2012 Oct | 22904286 |
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| Diagram | Functional Roles | Subsystem Spreadsheet | Description | Additional Notes | |||||||||
The copper ion is important for biological processes because it acts as a cofactor in many enzymes. The ycn operon encodes proteins that are utilized in copper uptake in copper-limiting conditions. The ycnK,copC, copD, and ycnI genes are polycistronic while the ycnL gene is monocistronic and read in the opposite direction. Copper efflux is encoded in the copZA operon with the csoR gene acting as the transcriptional repressor of the operon. Copper levels must be controlled in cells because too much copper leads to toxicity, but it is still required in small amounts for many enzymes to function properly. The ycn operon acts in copper uptake while the copZA operon acts in copper efflux. These two systems work together to keep the cellular copper levels in equilibrium. | |||||||||||||
