Subsystem: Modification of eukaryotic initiation factor 5A

This subsystem's description is:

The initiation factor 5A (IF-5A) of archaea and eukaryotes undergoes an unusual post-translational modification consisting of the transformation of a specific conserved lysine residue into the amino acid hypusine. This occurs in a two-step reaction catalysed by the enzymes deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase.

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Literature ReferencesHorizontal gene transfer and archaeal origin of deoxyhypusine synthase homologous genes in bacteria. Brochier C Gene 2004 Apr 1415087136
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The initiation factor 5A (IF-5A) of archaea and eukaryotes undergoes an unusual post-translational modification consisting of the transformation of a specific conserved lysine residue into the amino acid hypusine. This occurs in a two-step reaction catalysed by the enzymes deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase.
Gene. 2004 Apr 14;330:169-76.
Horizontal gene transfer and archaeal origin of deoxyhypusine synthase homologous genes in bacteria.
Brochier C, López-García P, Moreira D.