Subsystem: Triacylglycerol metabolism

This subsystem's description is:

Triacylglycerols are highly concentrated stores of metabolic energy due to their nearly anhydrous storage form and the high yield of free energy on oxidation. Not all known lipases hydrolyse triacylglycerols. Ones related to this function are listed in the subsystem. Most of these functions are more specific for eukaryotic metabolism and occur as well in plant and animal pathogens.

For more information, please check out the description and the additional notes tabs, below

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Group Alias
Abbrev.Functional RoleReactionsScenario ReactionsGOLiterature
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Taxonomy Pattern 
Organism 
Domain
Variant [?] 
active
AGKMGATDGATMAGL*TAGL*LPLPLA1PL
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Triacylglycerols are highly concentrated stores of metabolic energy due to their nearly anhydrous storage form and the high yield of free energy on oxidation. Not all known lipases hydrolyse triacylglycerols. Ones related to this function are listed in the subsystem. Most of these functions are more specific for eukaryotic metabolism and occur as well in plant and animal pathogens.
Variant code:
1-Diacylglycerol lypase, monoacylglycerol lipase and lysophospholipases are present
2-Diacylglycerol lypase, monoacylglycerol lipase are present
3-Monoacylglycerol lipase is present
8-Diacylglycerol lypase is present
2-Triacylglycerol lipase and Lysophospholipase present
5-Triacylglycerol lipase is present
6-Lysophospholipase and Lisophospholipase 2 are present
7-One Lysophospholipase of any type is present
9-Lysophospholipase2 and Phospholipase A1 are present

Notes:
2.7.1.94-no sequence, one match in ncbi: Q53H12
DEFINITION Multiple substrate lipid kinase, mitochondrial precursor
(Multi-substrate lipid kinase) (MuLK) (HsMuLK) (Acylglycerol
kinase) (hAGK).
MGAT: only eukaryotic (at least from known sequences)
Reference:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15939762&itool=iconfft&query_hl=1&itool=pubmed_docsum
The bioactive phospholipids, lysophosphatidic acid (LPA) and phosphatidic acid (PA), regulate pivotal processes related to the pathogenesis of cancer. Here, we report characterization of a novel lipid kinase, designated acylglycerol kinase (AGK), that phosphorylates monoacylglycerol and diacylglycerol to form LPA and PA, respectively.
http://www.jbc.org/cgi/reprint/261/12/5597
acylglycerol o-acyltransferase: ??
Adiponutrin (iPLA2-epsilon) [Includes: Triacylglycerol lipase ; Acylglycerol O-acyltransferase ]
gi|32469599|sp|Q9NST1|ADPN_HUMAN[32469599]

Currently selected organism: Anabaena variabilis ATCC 29413 (open scenarios overview page for organism)



ScenarioInput CompoundsOutput CompoundsPaint on MapStatus in 240292.3



Glycerophospholipid metabolism (link to KEGG)Glycerolipid metabolism (link to KEGG)